Ocular PK & Bioanalysis / Biodistribution Services at Pharmaron

Developing effective ocular therapies requires a deep understanding of how your test article interacts with the eye’s complex environment. Pharmaron offers comprehensive ocular pharmacokinetic (PK), bioanalysis, and biodistribution services, utilizing preclinical animal models and advanced analytical platforms to support your drug development program.

Our experts at Pharmaron will help design studies to address these complexities, ensuring your compound reaches its target at therapeutic concentrations. We specialize in understanding ocular drug delivery and ocular pharmacokinetics to maximize your chances of success.

Our Ocular PK Services:

Preclinical Animal Models for Ocular Studies: We expertly select appropriate animal models (e.g., rodents, rabbits, dogs, and pigs), based on your specific needs and target indication, ensuring translatability to human physiology. Our team has extensive experience in various administration routes, including topical, intravitreal, subretinal, suprachoroidal, subconjunctival, and systemic routes, covering a range of ocular disease models.

Capabilities

Ocular Toxicology

CGT Bioanalysis

CGT Ophthalmology

Ocular Devices

Ocular in vivo Pharmacology

Connect with a Scientific Expert

Ocular Sample Collection and Bioanalysis: Dedicated research associates proficient in ocular dissection for the collection and preservation of ocular matrices (aqueous humor, vitreous humor, lens tissue, retina, cornea, conjunctiva, etc.) at defined time points, maintaining sample integrity. We offer advanced bioanalytical services, with multiple platforms:
- LC-MS/MS for Ocular PK: Highly sensitive and specific quantification of your compound in various ocular matrices for detailed PK profiling, essential for ocular drug development.
- ELISA for Ocular Biomarkers: Measurement of key biomarkers related to your target indication, providing insights into the mechanism of action and efficacy in ocular therapeutics.
- PCR for Ocular Gene Expression Analysis: Gene expression analysis to assess the impact of your compound on ocular cellular processes, crucial for understanding ocular pharmacology.
Assay development, validation, and sample analysis from preclinical/GLP-tox through clinical phases
- Harmonized procedures and instrumentation between sites
- Method Development / Transfer and Validation as per regulatory requirements and industry standards
- Rigorous QC/QA program with data management
- “Fit-for-purpose” Biomarker qualification and sample analysis
- Cross-validation
- Automated analysis workflows
- Assay life-cycle management