Antibody-drug Conjugates
Antibody-Drug Conjugates (ADC) Services
Pharmaron can help our partners with the entire bioconjugation synthesis process, including linker drug generation, antibody expression, purification, and bioconjugation. Pharmaron’s team has years of experience generating high-potency payloads and linker payloads from the discovery stage to GMP manufacturing.
Pharmaron’s team has built capabilities to express and purify protein and cell line optimization from the discovery to the process development stage, and GMP services will be available next year.
Our integrated drug discovery approach allows our team to generate the bioconjugate and even test them?in vitro?and?in vivo?assays for efficacy, stability, PK, and toxicology.
Conjugation Chemistries
- Via Cystine – Intrachain disulfides, site specific
- Via Lysine
QC Packages
- Concentration
- DAR
- % monomer
- Endotoxin level
- % free payload present in final bulk
- Peptide mapping
Laboratory Chemistry Services
Pharmaron provides efficient and innovative services in support of medicinal chemistry and drug discovery research.