Medical Devices Animal Models

A ventilator machine displaying patient vitals in a modern, sterile operating room with blurred medical equipment in the background.

Medical Devices Animal Model Services

Pharmaron’s nonclinical medical device animal models include in vivo and ex vivo options for implantable devices. Our team supports medical device implantation in vivo for acute and chronic evaluation. Our fully accredited facilities support many clinically relevant disease states and surgical models.

We have access to board-certified pathologists with the option for onsite pathology support and onsite support from attending veterinarians to ensure studies comply with all applicable animal welfare guidelines and regulations. All animal studies are performed at facilities that are AAALAC-accredited and GLP-compliant. We have experience with multiple test species plus ocular disease models, including glaucoma, AMD, KCS, and CNV.

Animal species

  • Rodents
  • Rabbits
  • Dogs
  • Pigs/mini-pigs (Yorkshire, Gottingen, Yucatan)
  • Sheep
A fully equipped, modern surgical room with monitoring devices, operating table, and medical equipment, prepared for a medical device safety assessment.

Vascular Device Testing (Cardiovascular, Neurovascular)

  • Implantable medical devices: acute or long-term implantation surgeries in porcine or ovine models
  • Acute cardiovascular injury models: vascular surgeries, e.g., thrombectomy & vessel cauterization
  • Cardiovascular disease states: Systemic and localized cardiovascular disease states
  • Modalities for cardiovascular evaluation: fluoroscopy, imagine (C-Arm), ultrasound, intra-cardiac echocardiography, transthoracic echocardiogram
  • Disease models: aneurysm, myocardial infarct, deep vein thrombosis
close up on contact lens

Ocular Device Testing

  • Preclinical studies from POC to establish disease models to IND-enabling GLP-tox and safety studies using models with multiple disease states
  • Ocular devices range from everyday daily-use items to novel orbital implants, pumps, and drug-delivery devices for the treatment of chronic conditions
  • Imagine modalities for anterior/posterior evals: slit lamp biomicroscopy, gonioscopy, ocular coherence tomography, fundus imaging, electroretinography
  • Disease models: glaucoma, diabetic retinopathy, cataract, corneal defects, dry eye, AMD
Two glucose meters, syringes, and a lancing device placed on a blue fabric, representing medical devices used in animal models for diabetes research.

Metabolic Disease Testing and Blood Glucose Monitoring

  • Continuous glucose monitoring
  • HFD/STZ-induced experimental diabetes
  • Experimental models
    • NAFLD
    • NASH
  • Wound healing (acute and chronic models)
  • Diabetic retinopathy

On-demand Webinar

Learn more about why in vivo testing is needed for regulatory approval of a Medical Device and what specific testing is required.

Watch Our on-demand webinar
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