Inflammation, Immunology and Pain Models
Inflammation, Immunology & Pain Models for Efficacy Studies
Pharmaron provides CRO services in inflammation models, immunology models, and pain models (inflammatory pain models and neuropathic pain models) offering comprehensive preclinical services for the evaluation of therapies targeting these complex diseases. The team is supported by internal PK/bioanalytical, ex vivo pharmacology, and in vitro biology teams to provide integrated services.
Highly-Skilled Teams
Inflammation, immunology, and pain models require a high degree of scientific expertise to ensure accuracy and reproducibility in readouts such as animal behavior and physiological observations. Our teams provide the technical excellence and deep understanding of these models, ensuring reliable results.
Client-First Communication
Pharmaron prioritizes transparency and collaboration through direct communication between clients and scientists. This approach keeps clients informed with timely updates and ensures that study objectives are met with clarity and alignment.
Dedicated Teams for Disease Areas
Our dedicated study directors provide consistency and reliability across inflammation, immunology and pain models, ensuring minimal variability in readouts.
Study Types
- Development and validation of disease models
- Maximum tolerated dose studies
- Dose range finding studies
- Efficacy studies
- PK/PD studies
Acute Inflammatory Models
Pharmaron’s acute inflammatory pain models are designed to assess pain-related responses driven by inflammation. These models provide critical insights into pain mechanisms, drug efficacy, and therapeutic potential, supporting the development of effective analgesics.
- Air pouch model
- LPS-induced cytokine release model
- R848-induced cytokine release model
- Delayed-Type hypersensitivity
- Passive cutaneous anaphylaxis (PCA)
- Mono iodoacetate (MIA)-induced rat model
- Tail flick model
Immunology and Autoimmune Disease Models
Pharmaron’s in vivo pharmacology team possesses a broad portfolio of validated immunology and autoimmune disease models for robust efficacy evaluation of test articles.
- Wound healing model
- Inflammatory bowel disease (IBD) model
- Asthma model
- Arthritis model
- Skin inflammation models (atopic dermatitis, psoriasis, alopecia, and more)
- Systemic lupus erythematosus model
- Type I diabetes animal model
Acute Inflammatory Pain Models
Our acute inflammatory pain models enable the exploration of inflammation-pathway mechanisms, providing insights into drug action and potency for therapeutic development.
- Carrageenan-induced paw edema
- Formalin test
- Complete Freund’s adjuvant (CFA) model
- Nerve growth factor (NGF) model
- Wound healing model
- Paw incision model
- Acetic acid (AcOH)-induced writhing model
- MSU-induced gout arthritis model
- Ocular inflammation models
Neuropathic Pain Models
Pharmaron’s in vivo pharmacology team offers a comprehensive range of neuropathic pain models to assess the efficacy of analgesics and neuroprotective agents.
- Chronic constriction injury model (CCI; Bennett model)
- Spared nerve injury (SNI) model
- Vincristine-induced peripheral neuropathic pain model
- Bortezomib-induced peripheral neuropathy pain model
- Paclitaxel-induced peripheral neuropathy pain model
- Cancer-induced bone pain(CIBP) model
- Nitroglycerin (NTG)-induced migraine rat model
Physiological and Behavioral Readouts
To accurately evaluate the therapeutic effects of treatments, Pharmaron provides a diverse range of physiological and behavioral readouts, ensuring precise and reliable measurement of study outcomes.
- Inflammation and edema: Paw volume, joint swelling, paw thickness
- Pain sensitivity: Tail flick test, von Frey filament test, hot plate test, cold plate test, Hargreaves test, weight bearing test, paw pressure, behavioral gait analysis
Biomarker and Bioanalysis Platforms
Our advanced platforms facilitate the measurement and analysis of disease-specific biomarkers and drug concentrations. These platforms enable precise measurement and analysis, ensuring clients receive actionable insights to advance their therapeutic development.
- Matrices: blood, tissue, urine, feces, other body fluids
- Drug concentration quantification
- Disease-specific biomarker analysis
- Gene and protein evaluations
- Flow cytometry
- Histology and IHC
- Hematology, blood chemistry, urinalysis, and coagulation
Pharmaron’s integration of technology and expertise in inflammation, immunology, and pain models along with biomarker, bioanalysis and behavior platforms ensures comprehensive solutions, helping clients overcome research challenges and accelerate therapeutic advancements.
Related Resources
in vivo Mouse Model for Optic Neuropathy
Neuropathy Drug Testing via Cancer-induced Bone Pain Model
