Cell-Based Assays

Pharmaron’s cell-based assay services encompass the entire spectrum of cell biology—from standard IC50 doses to custom-tailored analyses of cellular responses to drug treatment. Our state-of-the-art technologies, including fully automated high-throughput screening via high-content imaging, push the boundaries of data-driven drug discovery.

Strategically co-located with our in vivo pharmacology, laboratory chemistry, and DMPK divisions, our cell-based assay services benefit from streamlined compound logistics, accelerating turnaround times, and DMTA cycles. For example, we execute routine cell-based assays within a 5-day turnaround from order to report.

Pharmaron’s cell-based assays vary in complexity according to project goals. We work with immortalized cell lines, disease-relevant primary cells, and advanced 3D models such as organoids derived from PDX tumors. These advanced cell biology readouts provide robust and clinically relevant findings.

Our unmatched expertise in cell-based assay services enables us to offer unparalleled functional assays and phenotypic screening with over 2,000 cell lines at our disposal:

Cell Models

• Human cancer cell lines
• Human normal cell lines
• Rodent cancer cell lines
• Organoids
• Primary cells (whole blood, immune cells, microglia, etc.)
• Drug-resistant cell lines
• iPSCs (cardiomyocyte, neuron, etc.)
• Engineered cell lines

Our cell line engineering department supports the development of cell-based assays.