Integrated?in vitro?and?in vivo?ADME

A scientist wearing blue gloves carefully pours blue liquid from a flask into a test tube in a laboratory setting. The background is blurred, emphasizing the precise handling of chemicals. in radiosynthesis and radiolabelling services for ADME

Integrated in vitro and in vivo ADME to Enable Rapid Decision Making

Understanding drug ADME’s mechanisms, rates, and routes is essential in discovery and development.  Whether the focus is on lead optimization, candidate identification or profiling, or preparing for Investigational New Drug (IND) or New Drug Application (NDA) regulatory submissions, Pharmaron’s integrated in vitro and in vivo ADME services can deliver extensive support. 

Pharmaron works closely with our clients as a fully integrated partner, guiding them through the process and providing timely, high-quality data while simplifying and expediting program decisions. Our strong scientific experience allows us to build consultative relationships to drive NCEs and NBEs through Discovery and Development and beyond.

View our on-demand webinars within our DMPK series, covering a spectrum of interesting DMPK topics.

Infographic showing the early discovery to IND process, highlighting integrated in vitro and in vivo ADME studies, PKPD, human prediction, and IND/clinical strategy.

A fully integrated partner:

  • Our cross-functional team of experienced DMPK scientists and leaders covers all aspects of DMPK, from drug discovery to regulatory submission and everything in between. 
  • Our consultancy-based approach provides strategic and experimental guidance and continuity.
  • Our facilities support non-GLP, GLP, and GCP-compliant bioanalytical services, minimizing the need for technology transfers.
  • Data are delivered to meet all requirements, spanning rapid data upload during DMTA cycles to regulatory reports.
  • Pharmaron offers a one-stop shop for continuous solutions, reducing the cost and complexity of sourcing solutions from multiple specialist vendors.
A person wearing a lab coat, face mask, safety glasses, and blue gloves operates a touchscreen panel on a large, white machine in a clean, bright laboratory setting focused on in vitro biology process optimization.

Capabilities

  • In vitro ADME
  • Rodent PK
  • Non-Rodent PK
  • In vivo ADME PKPD
  • Metabolite Identification
  • IND/DDI Studies
  • Metabolite Profiling (MIST)

Access our Integrated ADME Service Infographic

Download Our Service Overview
Service overview graphic promoting Pharmaron's integrated in vitro and in vivo ADME solutions, highlighting early discovery to IND, and offering a PDF download.

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