Developmental and Reproductive Toxicology

A gloved scientist adjusts a centrifuge filled with small test tubes, preparing samples for general toxicology analysis.

Developmental and Reproductive Toxicology (DART) Services

Pharmaron provides developmental and reproductive toxicology (DART) services to evaluate agents for the life sciences industry. The DART team offers comprehensive studies to evaluate developmental and reproductive toxic potential. They also offer customized study designs, such as ePPND.

DART Study Designs:

  • Fertility and early embryonic development
  • Embryo-fetal development
  • Perinatal and postnatal development
  • Prenatal developmental toxicity
  • One-Generation reproduction toxicity
  • Two-Generation reproduction toxicity
  • Reproduction/developmental toxicity screen
  • Extended one-generation reproductive toxicity
A scientist's gloved hand operates a lab instrument analyzing a multi-well plate with yellow samples, used for developmental and reproductive toxicology testing.

Segment I Study Designs

  • Maturation of gametes
  • Mating behavior
  • Fertility
  • Pre- and post-implantation development
  • Sperm analysis
A gloved scientist uses a pipette to transfer a yellow liquid into a small vial during a Developmental and Reproductive Toxicology (DART) study.

Segment II Study Designs

  • Maternal toxicity
  • Embryotoxicity
  • Fetotoxicity
  • Teratogenicity (fetal external evaluation, fetal soft tissue evaluation, fetal skeletal evaluation)
A microplate with yellow and clear liquid samples inserted into a reader, used for developmental and reproductive toxicology testing.

Segment III Study Designs

  • Development landmarks
  • Sensory functions 
  • Motor activity
  • Learning and memory
  • Reproductive function

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