Achieving the Chemistry Trifecta: Efficient, Safe & Green
With every chemistry project, Pharmaron is committed to implementing innovative ways to improve efficiency, ensure the basis of safety, and increase sustainability. Technologies such as high-throughput reaction screening, biocatalysis, and flow chemistry are vital to achieving these critical goals.
Our automated high throughput reaction screening platform leveraging ChemSpeed and Quantos hardware has shown excellent time-saving and optimization results for process, development manufacturing, and discovery chemistry settings. For example, the solid dispensing tool allows for solid base/additives to be dispensed faster and more accurately without the need to weigh each vial individually. Pharmaron has also built custom data analysis and visualization workflows, allowing a rapid understanding of the optimization landscape.
Biocatalysis is an efficient and effective method to catalyze chemical reactions by using natural substances that include enzymes from biological sources or whole cells. Biocatalysis simplifies processing and purification for scale-up compound production as it generates fewer by-products, reduces steps since protecting/deprotecting isn’t required, and has high stereo-selection, which avoids chiral separation.
Flow chemistry continues to be a practical approach to reaction selectivity. With its ability to run a reaction in a continuous stream rather than a batch production, the output is faster, more efficient, and safer. We recently completed a 440kg flow chemistry campaign. After optimization, the cost decreased by 30% through increased process efficiency and solvent usage reduction by 44%.
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