Poster Authors:

Yuhui Wang, Lin Feng, Han Liu, Qiuyuan Yang, Junwen Zhang, Kaiqiang Hu, Pengwei Pan, Fang He

Pharmaron (Beijing) Co., Ltd, Beijing, China

PDX?Derived Organoids as Predictive Models for Cancer Drug Response

Tumor organoids are increasingly recognized as predictive preclinical cancer models because they reflect original tumor features and patient drug responses. However, systematic comparisons between organoids and traditional 2D cell lines or 3D spheroids are lacking. In this study, we compared the response of PDXO models and traditional tumor cell line models to clinical cancer drugs. Drug efficacy and multi-omics data from the organoid models are the basis for predicting the clinical drug response in this promising in vitro model and identifying potential drug resistance mechanisms.