Recorded: July 2023

This webinar showed challenges and complexities of working with protein degraders and how these can be overcome to allow DMPK data to be incorporated in medicinal chemistry design.

Agenda

  • What are the challenges in assessing DMPK properties for protein degraders?
    • The characteristics of protein degraders and the challenges in assessing their DMPK properties
  • How do we assess ADME properties for protein degraders?
    • in vitro methods to assess ADME properties for protein degraders in discovery projects – theoretical and practical aspects of the methods
  • How do we use DMPK data to guide structure optimization for protein degraders?
    • General principals of using DMPK data to optimize structure for protein degraders to improve their DMPK properties