Direct-to-Biology: With Speed to Lead

Pharmaron poster promoting its Direct-to-Biology (D2B) approach to drug discovery with download option on a molecule-themed background.

Poster Authors:

Chris Wellaway1, Sebastien Campos1, Peng Chen2, Pengxia Ding3, Qifeng Fu?, Chunyan Han3, Zhengqiao Huang?, Tong Jiang3, Christian Kuper1, Lei Liu3, Manlin Liu3, Ruixue Liu?, Dan Moseley1, Steven Sollis1, Alison Stewart1, Zixuan Tong1, Yongcheng Wang2, Joanne Wayne1, Qiming Xiang?, Yaoshun Yang3, Wenjie Ye?, Rong Zhang3, Jie Zhao2, Xin Zhao?, Ziwei Zhao2

1 Pharmaron UK Ltd, Hoddesdon, UK

2 Pharmaron, Xi’an, China

3 Pharmaron, Beijing, China

4 Pharmaron, Ningbo, China

Testing of Direct Reaction Mixture for Shorter DMTA Cycles through D2B Drug Discovery

This poster was presented at the ELRIG Drug Discovery 2025.

Direct-to-Biology (D2B) represents a transformative advance in drug discovery. By testing unpurified reaction mixtures directly in biological assays, D2B drug discovery accelerates the Design-Make-Test-Analyze (DMTA) cycle, reducing time, resource investments, and overall costs.

In this poster, we present Pharmaron’s D2B drug discovery platform for the discovery and optimization of Bifunctional Targeted Protein Degraders (TPDs).

Key Insights from our Direct-to-Biology Poster

  • Established D2B Drug Discovery Platform: We have successfully validated a D2B platform specifically designed for bifunctional targeted protein degraders, supported by a diverse toolbox of E3 ligase binders and linkers.
  • Validated Automation: The  automated direct-to-biology chemistry workflow is validated in both 96-well and 384-well formats, achieving high conversion rates for reaction types like SNAr and amide coupling.
  • High Data Agreement: Our results show excellent agreement between data from unpurified, micropurified, and purified compounds, confirming the reliability and robustness of our D2B drug discovery service.
  • Study Examples: We identify hits and reveal Structure-Activity Relationships (SAR) for BRD4 and AR-FL, demonstrating the practical impact of our platform.

Download the poster to gain deeper insight into our discovery-to-biology service, validation data, and example data.