Development of in vitro potency assays to evaluate early activation, Granzyme B secretion, and cytotoxicity of CAR-T cells

Poster titled "Development of in vitro potency assays to evaluate early activation, Granzyme B secretion, and cytotoxicity of CAR-T cells," featuring detailed charts and graphs. The background includes purple and blue geometric patterns with the Pharmaron logo in the bottom right corner, underlining their expertise in bioanalytical development. A download button is provided below.

Poster Authors:

Jiu Jiang, Lisa Yu, Rachana Patel, Sicco Popma, and Sid Bhoopathy

Pharmaron US Lab Services l Exton, Pennsylvania

CD19-redirected chimeric antigen receptor (CAR) T cells have been successfully used in treating patients with B-cell leukemia. The purpose of this study was to develop in vitro potency assays for determining early activation and cytotoxicity of CAR-T cells.