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Poster for a scientific presentation on the in vitro evaluation of CAR-T cell cytotoxicity using flow cytometry for developing potency assays. Promoted by CAR-TCR and Pharmaron, with insights into genetic toxicology. "Download Posters Below" call to action. Background features a DNA helix graphic.

Poster Authors:

Jiu Jiang, Hui Yu, Imelda Mema, Rachana Patel, Wayne Zhou, and Sid Bhoopathy

Pharmaron – Exton, Pennsylvania

Flow Cytometry Insights Into CAR?T Cell Cytotoxicity

CD19 redirected chimeric antigen receptor (CAR) T cells have been successfully used in treating patients with B-cell leukaemia. In this study, we evaluated CD19 CAR-T cell cytotoxicity in vitro using flow cytometry for development of a potency assay The killing efficiency, the dose of the effectors, the time of co culture, the activation of CAR-T cells, and IFNy production have been examined

Capabilities

Knowledge Center

Cell-Based Potency Assays

CAR-T Cell Therapy Development & Testing

GMP Analytical Platforms

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