ISSX 2025 - 14th International Meeting
Join Pharmaron from September 21st to 24th at ISSX 2025
Pharmaron will be exhibiting at the 14th ISSX International Meeting from September 21–24, 2025, in Chicago, IL. at the Hilton Chicago. Pharmaron offers an end-to-end solution from discovery through clinical development. Our comprehensive expertise in Carbon-14 and tritium radiolabelling for ADME studies, including QWBA tissue distribution and in vitro cross-species comparative metabolism data, provides critical insights for selecting toxicology species, predicting compound distribution and metabolism, and bridging non-clinical and clinical studies. Early-stage screening and regulatory-compliant toxicology studies seamlessly transition from lead optimization to IND-enabling studies.
Please schedule a meeting with our team below to discuss your requirements and challenges related to hit identification, lead optimization, candidate selection, formulation, in vitro /in vivo profiling, DMPK, IND submission, or clinical development.
Our ISSX 2025 Schedule
Exhibit Booth # 307
Exhibit Hours
- Monday, September 22 – 9:30 a.m. – 7:30 p.m.
- Tuesday, September 23 – 9:30 a.m. – 7:30 p.m.
- Wednesday, September 24 – 9:30 a.m. – 2:30 p.m.
With presentations scheduled every day of the show, you have several opportunities to engage with our experts, explore how their research applies to your programs, and connect in person. Our advanced capabilities and depth of expertise are designed to help accelerate your success, while keeping us, and our partners, at the forefront of the industry.
Talks and Posters
Monday, Sept. 22 Talks and Posters
Talk:
1:45 PM in the Exhibit Hall Presentation Area
- Marie Croft, Scientific Director of Radiolabelled Sciences, Presenting: Accelerator Mass Spectrometry in Drug Development: Clinical Applications and Technological Advances
Accelerator Mass Spectrometry (AMS) is increasingly used in drug development to detect low levels of radiolabeled (14C) compounds, especially in clinical studies such as human absorption, metabolism, and excretion (hAME) and absolute bioavailability (hABA). Initially adopted for drugs with long half-lives or low exposure, AMS has gained broader acceptance following industry recommendations and FDA guidance. It is particularly valuable when conventional methods like liquid scintillation counting lack sensitivity, such as in studies with low plasma concentrations of parent drugs or metabolites.
In this presentation, we demonstrate the clinical applications and technological advancements of AMS, including its evolution from early graphite-based systems to the latest low-energy Ionplus LEA platforms now operational across Pharmaron’s global network.
Posters in Continental B/C :
- Jessica Richardson, Senior Programme Manager, Metabolism
Tuesday, Sept. 23 Posters in Continental B/C
12:30–1:30 PM
- Marie Croft, Scientific Director of Radiolabelled Sciences:
- Download the Poster (P119): Review of AMS mass balance recoveries for FDA-approved drugs
- Chunyan Hun, Executive Director, DMPK
- Guru Valicherla, Senior Scientist II, Regulatory in vitro ADME
- Igor Mezine, Principal Research Fellow
1:30–2:30 PM
- Chunyan Hun, Executive Director, DMPK
- Download the Poster (P96): Co-culture rat brain microvascular endothelial cells and pericytes for high-throughput prediction of drug BBB permeability: validation with in vivo correlations
- Download the Poster (P94): Dissecting the impact of hepatocyte inactivation strategies on drug binding in primary hepatocyte assays
- Download the Poster (P78): LC-MS-based cholinesterase inhibition assay: high-sensitivity screening of inhibitors using recombinant ACHE and BCHE
- Download the Poster (P66): Determination of scaling factor ‘D’ for CYP induction studies
Wednesday, Sept. 24 Posters in Continental B/C
1:30–2:30 PM
- Chunyan Hun, Executive Director, DMPK
- Download the Poster (P202): LC-MS/MS targeted proteomics for precise quantification of P-glycoprotein in cell models
- Jessica Richardson, Senior Programme Manager, Metabolism
- Download the Poster (P140): 14C-Radiolabelled Human AME: A review of clinical mass balance data
Our scientists are eager to discuss how their findings can help advance your programs.
About the ISSX
The 14th International ISSX Meeting will focus on emerging technologies and innovations in drug metabolism, pharmacokinetics, and drug transport research. The event will feature expert-led short courses, scientific debates, poster presentations, and state-of-the-art exhibits, making it an essential gathering for researchers and industry leaders.
For more information and event registration, please visit the ISSX website.
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Meeting Request Form
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